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Latest Articles on Chikungunya

  • Wolbachia wAlbB remains stable in Aedes aegypti over 15 years but exhibits genetic background-dependent variation in virus blocking Mon, 30 Jan 2023 06:00:00 -0500
    The ability of the maternally transmitted endosymbiotic bacterium Wolbachia to induce cytoplasmic incompatibility (CI) and virus blocking makes it a promising weapon for combatting mosquito-borne diseases through either suppression or replacement of wild-type populations. Recent field trials show that both approaches significantly reduce the incidence of dengue fever in humans. However, new questions emerge about how Wolbachia-mosquito associations will co-evolve over time and whether...
  • Broad-spectrum antiviral inhibitors targeting pandemic potential RNA viruses Mon, 30 Jan 2023 06:00:00 -0500
    RNA viruses continue to remain a clear and present threat for potential pandemics due to their rapid evolution. To mitigate their impact, we urgently require antiviral agents that can inhibit multiple families of disease-causing viruses, such as arthropod-borne and respiratory pathogens. Potentiating host antiviral pathways can prevent or limit viral infections before escalating into a major outbreak. Therefore, it is critical to identify broad-spectrum antiviral agents. We have tested a small...
  • Infections in travellers returning to the UK: a retrospective analysis (2015-2020) Sat, 28 Jan 2023 06:00:00 -0500
    CONCLUSIONS: None of the top five infections diagnosed by RIPL in travellers are vaccine-preventable, therefore understanding traveller demographics, destination-specific risk factors and encouraging preventative behaviours is the best available strategy to reduce the number of returning travellers who become infected. Prompt referral of acute samples with a detailed travel history, including purpose of travel and activities undertaken as well as dates and destinations can be a valuable tool in...
  • Congenital chikungunya in a neonate with early-onset sepsis and petechiae: An unusual case report Fri, 27 Jan 2023 06:00:00 -0500
    Chikungunya, a mosquito-borne disease, is posing threat to neonatal population in Cambodia because of its challenging diagnosis and insufficient attention compared with Dengue. In what follows, we present a case of serologically-confirmed congenital chikungunya in a newborn presenting early-onset sepsis, and the mother was underdiagnosed with intrapartum flu-like infection.
  • The research progress of Chikungunya fever Thu, 26 Jan 2023 06:00:00 -0500
    Chikungunya fever, an acute infectious disease caused by Chikungunya virus (CHIKV), is transmitted by Aedes aegypti mosquitoes, with fever, rash, and joint pain as the main features. 1952, the first outbreak of Chikungunya fever was in Tanzania, Africa, and the virus was isolated in 1953. The epidemic has expanded from Africa to South Asia, the Indian Ocean islands and the Americas, and is now present in more than 100 countries and territories worldwide, causing approximately 1 million...
  • Identification of mosquito proteins that differentially interact with alphavirus nonstructural protein 3, a determinant of vector specificity Wed, 25 Jan 2023 06:00:00 -0500
    Chikungunya virus (CHIKV) and the closely related onyong-nyong virus (ONNV) are arthritogenic arboviruses that have caused significant, often debilitating, disease in millions of people. However, despite their kinship, they are vectored by different mosquito subfamilies that diverged 180 million years ago (anopheline versus culicine subfamilies). Previous work indicated that the nonstructural protein 3 (nsP3) of these alphaviruses was partially responsible for this vector specificity. To better...
  • Dengue, chikungunya and Zika virus infections among Dutch travellers to Suriname: a prospective study during the introduction of chikungunya and Zika virus, 2014 to 2017 Wed, 25 Jan 2023 06:00:00 -0500
    BackgroundSuriname, a country endemic for dengue virus (DENV), is a popular destination for Dutch travellers visiting friends and relatives and tourist travellers. Chikungunya and Zika virus (CHIKV, ZIKV) were introduced in 2014 and 2015, respectively. Data on infection risks among travellers are limited.AimWe aimed to prospectively study incidence rate (IR) and determinants for DENV, ZIKV and CHIKV infection in adult travellers to Suriname from 2014 through 2017.MethodsParticipants kept a...
  • Chronic Bilateral Symmetric Anterior Shoulder Dislocation Secondary to Seizures in Chikungunya Encephalitis Wed, 25 Jan 2023 06:00:00 -0500
    Bilateral shoulder dislocations are a rare occurrence and can be categorized as either symmetric (both humeral heads dislocate in the same direction) or asymmetric (wherein the humeral heads dislocate in different directions). Shoulder dislocations may be overlooked if they are the result of systemic injury; if diagnosed >21 days after occurring, they are considered chronic dislocations. We describe the case of a 31-year-old male who presented with an eight-week history of bilateral shoulder...
  • Evaluation of Aedes aegypti Penetration, Probing, and Feeding Times on Mice Mon, 23 Jan 2023 06:00:00 -0500
    In mosquitoes, the intradermal search for vertebrate blood (probing time) corresponds to the time taken from initial insertion of the mouthparts in the skin until visualization of the initial engorgement of blood in the midgut. Probing time evaluation provides useful information on the ability of a mosquito to initiate successful blood feeding. In this protocol, we describe how to determine feeding parameters in Aedes aegypti, a widely distributed mosquito that transmits several deadly...
  • A comparative analysis of Aedes albopictus and Aedes aegypti subjected to diapause-inducing conditions reveals conserved and divergent aspects associated with diapause, as well as novel genes associated with its onset Mon, 23 Jan 2023 06:00:00 -0500
    Aedes albopictus and Aedes aegypti are mosquito species that are distributed worldwide and transmit diverse arboviruses of medical importance, such as those causing yellow fever, dengue, chikungunya and Zika. A. albopictus embryos may remain viable for long periods in the environment due to their ability to become dormant through quiescence or diapause, a feature that contributes to their dispersion and hinders control actions. Diapause incidence can vary among natural populations of A....

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