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Latest Articles on Chikungunya

  • Complete Inhibition of Vertical Mosquito Landing through Topographical Surface Design Fri, 12 Aug 2022 06:00:00 -0400
    Mosquito-borne diseases such as dengue, chikungunya, and malaria have long been a health and economic burden in our society. Such illnesses develop after the pathogen, here arboviruses, are transmitted to humans by female mosquitoes during blood meals. In the case of dengue and chikungunya, such pathogens are transmitted to humans by infected Aedes aegypti females. Prior to feeding the insects rest on vertical surfaces. In this work, a surface roughness threshold was observed for live Aedes...
  • The new invasive mosquito species Aedes koreicus as vector-borne diseases in the European area, a focus on Italian region: What we know from the scientific literature Fri, 12 Aug 2022 06:00:00 -0400
    The increased mobility of goods, people, and animals worldwide has caused the spread of several arthropod vectors, leading to an increased risk of animal and human infections. Aedes koreicus is a common species in South Korea, China, Japan, and Russia. Due to its cold-resistant dormant eggs, the adults last from the late summer until the autumn seasons. For these reasons, it seems to be better adapted to colder temperatures, favoring its colonization of hilly and pre-alpine areas. Its first...
  • CHIKV infection reprograms codon optimality to favor viral RNA translation by altering the tRNA epitranscriptome Thu, 11 Aug 2022 06:00:00 -0400
    Ample evidence indicates that codon usage bias regulates gene expression. How viruses, such as the emerging mosquito-borne Chikungunya virus (CHIKV), express their genomes at high levels despite an enrichment in rare codons remains a puzzling question. Using ribosome footprinting, we analyze translational changes that occur upon CHIKV infection. We show that CHIKV infection induces codon-specific reprogramming of the host translation machinery to favor the translation of viral RNA genomes over...
  • Aedes aegypti and Ae. albopictus microbiome/virome: new strategies for controlling arboviral transmission? Tue, 09 Aug 2022 06:00:00 -0400
    Aedes aegypti and Aedes albopictus are the main vectors of highly pathogenic viruses for humans, such as dengue (DENV), chikungunya (CHIKV), and Zika (ZIKV), which cause febrile, hemorrhagic, and neurological diseases and remain a major threat to global public health. The high ecological plasticity, opportunistic feeding patterns, and versatility in the use of urban and natural breeding sites of these vectors have favored their dispersal and adaptation in tropical, subtropical, and even...
  • TMEM41B and VMP1 modulate cellular lipid and energy metabolism for facilitating dengue virus infection Mon, 08 Aug 2022 06:00:00 -0400
    Transmembrane Protein 41B (TMEM41B) and Vacuole Membrane Protein 1 (VMP1) are two ER-associated lipid scramblases that play a role in autophagosome formation and cellular lipid metabolism. TMEM41B is also a recently validated host factor required by flaviviruses and coronaviruses. However, the exact underlying mechanism of TMEM41B in promoting viral infections remains an open question. Here, we validated that both TMEM41B and VMP1 are essential host dependency factors for all four serotypes of...
  • TMEΜ45B Interacts with Sindbis Virus Nsp1 and Nsp4 and Inhibits Viral Replication Mon, 08 Aug 2022 06:00:00 -0400
    Alphavirus infection induces the expression of type I interferons, which inhibit the viral replication by upregulating the expression of interferon-stimulated genes (ISGs). Identification and mechanistic studies of the antiviral ISGs help to better understand how the host controls viral infection and help to better understand the viral replication process. Here, we report that the ISG product TMEM45B inhibits the replication of Sindbis virus (SINV). TMEM45B is a transmembrane protein that was...
  • Changing Spectrum of Acute Encephalitis Syndrome in India and a Syndromic Approach Mon, 08 Aug 2022 06:00:00 -0400
    Acute encephalitis syndrome (AES) refers to an acute onset of fever and clinical neurological manifestation that includes mental confusion, disorientation, delirium, or coma, which may occur because of infectious or non-infectious causes. Cerebrospinal fluid (CSF) pleocytosis generally favors infectious etiology, and a normal CSF favors an encephalopathy or non-infectious AES. Among the infectious AES, viral, bacterial, rickettsial, fungal, and parasitic causes are the commonest. Geographical...
  • Impact of Antecedent Infections on the Antibodies against Gangliosides and Ganglioside Complexes in Guillain-Barré Syndrome: A Correlative Study Mon, 08 Aug 2022 06:00:00 -0400
    BACKGROUND AND AIMS: Guillain-Barré Syndrome (GBS), an immune-mediated neuropathy, is characterized by antibodies against gangliosides/ganglioside complexes (GSCs) of peripheral nerves. Antecedent infections have been reported to induce antibodies that cross-react with the host gangliosides and thereby have a pivotal role in conferring an increased risk for developing GBS. Data pertaining to the impact of various antecedent infections, particularly those prevalent in tropical countries like...
  • Chikungunya virus nsP1 induces migrasome formation Sat, 06 Aug 2022 06:00:00 -0400
    No abstract
  • Identification of the extracellular metallo-endopeptidases ADAM and ADAMTS in the yellow fever mosquito Aedes aegypti Sat, 06 Aug 2022 06:00:00 -0400
    The mosquito Aedes aegypti is a major vector for dengue, Zika, yellow fever, and chikungunya (CHIKV) viruses, which cause significant morbidity and mortality among human populations in the tropical regions of the world. Following ingestion of a viremic bloodmeal from a vertebrate host, an arbovirus needs to productively infect the midgut epithelium of the mosquito. De novo synthesized virions then exit the midgut by traversing the surrounding basal lamina (BL) in order to disseminate to...

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