Chikungunya Virus Net is the web resource for anyone interested in chikungunya. Chikungunya virus (CHIKV) is an insect-borne virus, of the genus Alphavirus, that is spread by Aedes mosquitoes. Chikungunya infection causes fever and severe joint pain. Other symptoms include muscle pain, headache, nausea, fatigue and rash. The disease shares some clinical signs with dengue, and can be misdiagnosed in areas where dengue is common. There have been recent breakouts of chikungunya in Africa, Asia and the Indian subcontinent. In recent decades mosquito vectors of chikungunya have spread to Europe and the Americas. In 2007, disease transmission was reported for the first time in Europe. There is no cure for the disease. Treatment is focused on relieving the symptoms.

The objectives of Chikungunya Virus Net are to be the public and professional information resource for chikungunya and to serve as a network in the exchange of information and news related to chikungunya.

• Chikungunya: the disease caused by bites from mosquitoes - Emergency Live International
  Wed, 30 Nov 2022 07:56 GMT
• Study shows sylvatic origin of chikungunya virus transmission among nonhuman primates of Myanmar - News-Medical.Net
  Tue, 22 Nov 2022 13:44 GMT
• Emergex Generates Chikungunya Ligandome, a Milestone in the Development of its T cell Adaptive Vaccine - Yahoo Finance
  Mon, 28 Nov 2022 12:00 GMT
• Beware, one mosquito bite could leave you with both dengue, chikungunya: PGI finding - Hindustan Times
  Fri, 25 Nov 2022 21:40 GMT
• Chikungunya cases up 589% – DOH - Philstar.com
  Sat, 26 Nov 2022 16:00 GMT
• Emergent scores a DoD award to evaluate its chikungunya vaccine in the field - Endpoints News
  Thu, 17 Nov 2022 08:00 GMT
• Student Infected With Debilitating Virus in Undisclosed Biolab Accident - The Intercept
  Tue, 01 Nov 2022 07:00 GMT
• Lower exposure in past 5 years 'behind' chikungunya surge - The Tribune India
  Sat, 19 Nov 2022 08:00 GMT
• What is Chikungunya? Symptoms, Causes, Diagnosis, Treatment, & Prevention - The Quint FIT
  Fri, 04 Nov 2022 07:00 GMT
• Paraguay: Dengue and chikungunya cases on the rise - Outbreak News Today - Outbreak News Today
  Thu, 24 Nov 2022 17:12 GMT
• 45 chikungunya cases, highest in four years - The Tribune India
  Sun, 13 Nov 2022 08:00 GMT
• Chikungunya Vaccine Candidate Posts Positive Phase 2 Results - Precision Vaccinations
  Wed, 02 Nov 2022 07:00 GMT
• Paraguay reports increase in chikungunya and dengue patients - Prensa Latina
  Fri, 18 Nov 2022 08:00 GMT
• Chikungunya: Phase 3 Clinical Development of a Single-shot Live-Attenuated Vaccine (Presentation at the American Society of Tropical Medicine & Hygiene) - Marketscreener.com
  Wed, 02 Nov 2022 07:00 GMT
• Dengue cases rise in city, chikungunya and malaria retreat - Times of India
  Tue, 08 Nov 2022 08:00 GMT

• PRO/AH/EDR> Rift Valley fever - Sudan: (NO) livestock, human, susp, RFI
  Wed, 15 Sep 2021 20:49:58 -0400
  Rift Valley Fever -- Sudan
  Doctors in Sudan's Northern State have reported 27 deaths and 68 [abortions] among livestock in the area of El Nafaab in Merowe locality and warn of the emergence of cases of Rift Valley fever [RVF] and chikungunya, similar to last year [2020]. They have appealed to the Ministry of Health and the state government to deal with the potential epidemic in a safe manner.
  In a press statement on Sunday [5 Sep 2021], the Socialist Doctors Association reported that a resident of the state arrived

• Molecular architecture of the Chikungunya virus replication complex Wed, 30 Nov 2022 06:00:00 -0500
  To better understand how positive-strand (+) RNA viruses assemble membrane-associated replication complexes (RCs) to synthesize, process, and transport viral RNA in virus-infected cells, we determined both the high-resolution structure of the core RNA replicase of chikungunya virus and the native RC architecture in its cellular context at subnanometer resolution, using in vitro reconstitution and in situ electron cryotomography, respectively. Within the core RNA replicase, the viral polymerase...
• Defective viral genomes from Chikungunya virus: A new broad-spectrum antiviral approach? Wed, 30 Nov 2022 06:00:00 -0500
  No abstract
• Anti-Arbovirus Antibodies Cross-React With Severe Acute Respiratory Syndrome Coronavirus 2 Tue, 29 Nov 2022 06:00:00 -0500
  Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is found in regions where dengue (DENV) and chikungunya (CHIKV) viruses are endemic. Any serological cross-reactivity between DENV, CHIKV, and SARS-CoV-2 is significant as it could lead to misdiagnosis, increased severity, or cross-protection. This study examined the potential cross-reactivity of anti-DENV and CHIKV antibodies with SARS-CoV-2 using acute and convalescent-phase samples collected before the SARS-CoV-2 pandemic. These...
• Chikungunya virus (CHIKV) seroprevalence in the South Pacific populations of the Cook Islands and Vanuatu with associated environmental and social factors Mon, 28 Nov 2022 06:00:00 -0500
  CONCLUSION: This is the first seroprevalence study focussing on an arboviral disease in the Cook Islands and Vanuatu. It highlights the impact of the 2014/2015 CHIKV epidemic on the Cook Islands population and shows that a notable part of the Vanuatu test population was exposed to CHIKV although no outbreaks were reported. Our findings supplement the knowledge concerning CHIKV epidemics in the South Pacific Region and contribute to a better understanding of virus dissemination, including...
• The DEAD-box RNA helicase Dhx15 controls glycolysis and arbovirus replication in Aedes aegypti mosquito cells Mon, 28 Nov 2022 06:00:00 -0500
  Aedes aegypti mosquitoes are responsible for the transmission of arthropod-borne (arbo)viruses including dengue and chikungunya virus (CHIKV) but in contrast to human hosts, arbovirus-infected mosquitoes are able to efficiently control virus replication to sub-pathological levels. Yet, our knowledge of the molecular interactions of arboviruses with their mosquito hosts is incomplete. Here, we aimed to identify and characterize novel host genes that control arbovirus replication in Aedes...
• Viral infections in orthopedics: A systematic review and classification proposal Mon, 28 Nov 2022 06:00:00 -0500
  CONCLUSION: Evidence of moderate strength suggested that viruses can cause moderate to severe arthritis and osteitis. Risk factors such as pre-existing rheumatologic disease contributed to higher disease severity and duration of symptoms. Therefore, based on our literature search, the proposed clinical and pathogenetic classification scheme is as follows: (1) Viral infections of bone or joint; (2) Active bone and joint inflammatory diseases secondary to viral infections in other organs or...
• The life cycle of the alphaviruses: From an antiviral perspective Sun, 27 Nov 2022 06:00:00 -0500
  The alphaviruses are a widely distributed group of positive-sense, single stranded, RNA viruses. These viruses are largely arthropod-borne and can be found on all populated continents. These viruses cause significant human disease, and recently have begun to spread into new populations, such as the expansion of Chikungunya virus into southern Europe and the Caribbean, where it has established itself as endemic. The study of alphaviruses is an active and expanding field, due to their impacts on...
• Antigenicity and immunogenicity of chikungunya virus-like particles from mosquito cells Sat, 26 Nov 2022 06:00:00 -0500
  The spread of chikungunya virus (CHIKV) is reaching pandemic levels, and vaccines and antivirals to control CHIKV infection have yet to be approved. Virus-like particles (VLPs), a self-assembled native multi-subunit protein structure, could potentially be used as an antigen for serological detection and vaccine development. In the current study, we describe the production of novel CHIKV VLPs from mosquitoes using a Baculovirus/Mosquito (BacMos) system in a simple Biosafety Level-2 laboratory....
• What sounds like Aedes, acts like Aedes, but is not Aedes? Lessons from dengue virus control for the management of invasive Anopheles Fri, 25 Nov 2022 06:00:00 -0500
  Aedes mosquitoes are responsible for transmission of dengue, chikungunya, Zika, and yellow fever viruses. Aedes mosquitoes are the pathfinders of invasive urban-living mosquitoes, and have spread into 129 countries over the past five decades. In the past 10 years Anopheles stephensi has been identified within densely populated cities in Yemen and across the Horn of Africa and as far west as Nigeria. A stephensi's aggressive spread is closely linked to increases in population movement due to...
• Expected endpoints from future chikungunya vaccine trial sites informed by serological data and modeling Thu, 24 Nov 2022 06:00:00 -0500
  In recent decades, there has been an increased interest in developing a vaccine for chikungunya. However, due to its unpredictable transmission, planning for a chikungunya vaccine trial is challenging. To inform decision making on the selection of sites for a vaccine efficacy trial, we developed a new framework for projecting the expected number of endpoint events at a given site. In this framework, we first accounted for population immunity using serological data collated from a systematic...