Chikungunya Virus Net is the web resource for anyone interested in chikungunya. Chikungunya virus (CHIKV) is an insect-borne virus, of the genus Alphavirus, that is spread by Aedes mosquitoes. Chikungunya infection causes fever and severe joint pain. Other symptoms include muscle pain, headache, nausea, fatigue and rash. The disease shares some clinical signs with dengue, and can be misdiagnosed in areas where dengue is common. There have been recent breakouts of chikungunya in Africa, Asia and the Indian subcontinent. In recent decades mosquito vectors of chikungunya have spread to Europe and the Americas. In 2007, disease transmission was reported for the first time in Europe. There is no cure for the disease. Treatment is focused on relieving the symptoms.

The objectives of Chikungunya Virus Net are to be the public and professional information resource for chikungunya and to serve as a network in the exchange of information and news related to chikungunya.

• Epidemiological Update: Dengue, Chikungunya and Zika in the context of COVID-19 (23 December 2021) - Argentina - ReliefWeb
  Fri, 24 Dec 2021 08:00 GMT
• The operation by the Municipal Health Service in Aberulandia targets dengue, Zika and chikungunya - brytfmonline.com
  Sun, 16 Jan 2022 07:17 GMT
• Mumbai: No dengue, H1N1 and chikungunya in January so far - Times of India
  Wed, 12 Jan 2022 03:29 GMT
• 23 December 2021: Dengue, Chikungunya and Zika in the context of COVID-19 - PAHO/WHO - Pan American Health Organization
  Thu, 23 Dec 2021 08:00 GMT
• Valneva says Chikungunya vaccine Phase 3 trial has met primary endpoint - Reuters
  Tue, 21 Dec 2021 08:00 GMT
• Valneva: Chikungunya vaccine trial met primary endpoint after positive phase 3 results - Nasdaq
  Tue, 21 Dec 2021 08:00 GMT
• Dengue, chikungunya cases in Ahmedabad spiked this year - Times of India
  Wed, 29 Dec 2021 08:00 GMT
• Over 32,000 people in the grip of Dengue, Malaria and Chikungunya in Maharashtra - eHealth Magazine - Elets
  Tue, 21 Dec 2021 08:00 GMT
• Chikungunya virus infection may develop partial immunity to Mayaro virus: University of São Paulo researchers - Outbreak News Today - Outbreak News Today
  Sat, 04 Dec 2021 08:00 GMT
• Chikungunya in the Americas: More than 120K cases reported, 97% in Brazil - Outbreak News Today - Outbreak News Today
  Sat, 30 Oct 2021 07:00 GMT
• Mapping Dengue Hot Spots Can Pinpoint Zika, Chikungunya Risk - PCT Magazine
  Tue, 20 Jul 2021 19:13 GMT
• Brazil: Chikungunya cases up dramatically in São Paulo - Outbreak News Today - Outbreak News Today
  Mon, 05 Jul 2021 07:00 GMT
• What chikungunya teaches us about COVID-19 - The Lancet
  Wed, 19 May 2021 07:00 GMT
• Chikungunya outbreak in Cambodia update - Outbreak News Today - Outbreak News Today
  Tue, 15 Jun 2021 07:00 GMT
• Valneva's chikungunya vaccine reports positive topline data from Phase 3 trial - BioPharma-Reporter.com
  Thu, 05 Aug 2021 07:00 GMT

• PRO/AH/EDR> Rift Valley fever - Sudan: (NO) livestock, human, susp, RFI
  Wed, 15 Sep 2021 20:49:58 -0400
  Rift Valley Fever -- Sudan
  Doctors in Sudan's Northern State have reported 27 deaths and 68 [abortions] among livestock in the area of El Nafaab in Merowe locality and warn of the emergence of cases of Rift Valley fever [RVF] and chikungunya, similar to last year [2020]. They have appealed to the Ministry of Health and the state government to deal with the potential epidemic in a safe manner.
  In a press statement on Sunday [5 Sep 2021], the Socialist Doctors Association reported that a resident of the state arrived

• Genetic characterization of Chikungunya virus circulating in individuals from Parana, Brazil Sat, 15 Jan 2022 06:00:00 -0500
  Phylogenetic analysis carried out in several Brazilian regions shows the circulation of the Asian and East-Central South African (ECSA) Chikungunya virus (CHIKV) genotypes in the country. Until now, there are no genetic studies about CHIKV strains circulating in the South region. In this study, we sequenced 5 new partial sequences of the CHIKV Envelope 1 gene from strains detected in Paraná state during the years 2016-2017. Maximum likelihood and neighbor-joining trees grouped all sequences in...
• Etiologies of acute undifferentiated febrile illness at the emergency ward of the University of Gondar Hospital, Ethiopia Fri, 14 Jan 2022 06:00:00 -0500
  CONCLUSION: Malaria is still a considerable etiology of AFI and dengue is underrecognized. There are areas where both diseases occur concomitantly, and the DENV-3 serotype spreads from Sudan to northern Ethiopia. As only 20.5% of the etiologies were identified, a broader testing platform is required.
• Effects of Sterile Males and Fertility of Infected Mosquitoes on Mosquito-Borne Disease Dynamics Fri, 14 Jan 2022 06:00:00 -0500
  By studying an infection-age structured model, we consider the effects of releasing sterile males and the fertility of infected mosquitoes on the mosquito-borne diseases transmission including the extinction of mosquitoes, the elimination and persistence of diseases. Firstly, equivalent integral equations are established to prove the well-posedness of solutions. Then, the main results of disease dynamics are given. By taking chikungunya as a numerical simulation example, an optimal releasing...
• Bivalent single domain antibody constructs for effective neutralization of Venezuelan equine encephalitis Fri, 14 Jan 2022 06:00:00 -0500
  Venezuelan equine encephalitis virus (VEEV) is a mosquito borne alphavirus which leads to high viremia in equines followed by lethal encephalitis and lateral spread to humans. In addition to naturally occurring outbreaks, VEEV is a potential biothreat agent with no approved human vaccine or therapeutic currently available. Single domain antibodies (sdAb), also known as nanobodies, have the potential to be effective therapeutic agents. Using an immune phage display library derived from a llama...
• The threat of mosquito-borne arboviral disease in Spain: A bibliographic review Fri, 14 Jan 2022 06:00:00 -0500
  Over the last two decades there has been an increase in outbreaks of arboviral diseases, being Spain at high risk for disease emergence. This paper reviews the current evidence regarding the transmissibility, disease epidemiology, control strategies and mosquito-borne disease drivers and maintaining factors in Spain. There is risk of autochthonous cases and outbreaks in Spain due to recent transmission occurrence. Recently, there has been an expansion of Aedes Albopticus, a vector for Dengue,...
• Machine learning and deep learning techniques to support clinical diagnosis of arboviral diseases: A systematic review Thu, 13 Jan 2022 06:00:00 -0500
  CONCLUSIONS: The use of an efficient clinical decision support system for arboviral diseases can improve the quality of the entire clinical process, thus increasing the accuracy of the diagnosis and the associated treatment. It should help physicians in their decision-making process and, consequently, improve the use of resources and the patient's quality of life.
• The global epidemiology of chikungunya from 1999 to 2020: A systematic literature review to inform the development and introduction of vaccines Wed, 12 Jan 2022 06:00:00 -0500
  Chikungunya fever is an acute febrile illness that is often associated with severe polyarthralgia in humans. The disease is caused by chikungunya virus (CHIKV), a mosquito-borne alphavirus. Since its reemergence in 2004, the virus has spread throughout the tropical world and several subtropical areas affecting millions of people to become a global public health issue. Given the significant disease burden, there is a need for medical countermeasures and several vaccine candidates are in clinical...
• Mutations at the Alphavirus E2/E1 inter-dimer interface have host-specific phenotypes Wed, 12 Jan 2022 06:00:00 -0500
  Alphaviruses are enveloped viruses transmitted by arthropod vectors to vertebrate hosts. The surface of the virion contains 80 glycoprotein spikes embedded in the membrane and these spikes mediate attachment to the host cell and initiate viral fusion. Each spike consists of a trimer of E2-E1 heterodimers. These heterodimers interact at two interfaces: (1) the intra-dimer interactions between E2 and E1 of the same heterodimer, and (2) the inter-dimer interactions between E2 of one heterodimer and...
• MARCH8 Targets Cytoplasmic Lysine Residues of Various Viral Envelope Glycoproteins Wed, 12 Jan 2022 06:00:00 -0500
  The host transmembrane protein MARCH8 is a RING finger E3 ubiquitin ligase that downregulates various host transmembrane proteins, such as MHC-II. We have recently reported that MARCH8 expression in virus-producing cells impairs viral infectivity by reducing virion incorporation of not only HIV-1 envelope glycoprotein but also vesicular stomatitis virus G-glycoprotein through two different pathways. However, the MARCH8 inhibition spectrum remains largely unknown. Here, we show the antiviral...
• Chikungunya outbreak in Bangladesh (2017): sociodemographic and clinical characteristics of patients from three hotspots Wed, 12 Jan 2022 06:00:00 -0500
  CONCLUSION: The clinical profile of chikungunya virus-induced disease displays significant location-related heterogeneity in Bangladesh during a large outbreak. Although the causes of such differences are unclear, improved public and medical personnel education on this condition may lead to earlier diagnosis and treatment.