Chikungunya Virus Net is the web resource for anyone interested in chikungunya. Chikungunya virus (CHIKV) is an insect-borne virus, of the genus Alphavirus, that is spread by Aedes mosquitoes. Chikungunya infection causes fever and severe joint pain. Other symptoms include muscle pain, headache, nausea, fatigue and rash. The disease shares some clinical signs with dengue, and can be misdiagnosed in areas where dengue is common. There have been recent breakouts of chikungunya in Africa, Asia and the Indian subcontinent. In recent decades mosquito vectors of chikungunya have spread to Europe and the Americas. In 2007, disease transmission was reported for the first time in Europe. There is no cure for the disease. Treatment is focused on relieving the symptoms.

The objectives of Chikungunya Virus Net are to be the public and professional information resource for chikungunya and to serve as a network in the exchange of information and news related to chikungunya.

• Valneva Completes Recruitment for Pivotal Phase 3 Trial of - GlobeNewswire
  Mon, 12 Apr 2021 07:00 GMT
• Brazil: Paraná reports increase in chikungunya cases - Outbreak News Today - Outbreak News Today
  Tue, 20 Apr 2021 07:00 GMT
• Tracking mosquito larvae to prevent Dengue, Chikungunya spikes - CGTN
  Sun, 02 May 2021 14:48 GMT
• Valneva recruits 4,131 US adults for Phase 3 trial of chikungunya vaccine candidate - Homeland Preparedness News
  Wed, 14 Apr 2021 07:00 GMT
• Bug Off: Advice for battling feisty mosquitoes this season - WJXT News4JAX
  Wed, 05 May 2021 16:42 GMT
• Chikungunya Vaccine Candidate: Valneva completes recruitment for Phase 3 trial - Outbreak News Today - Outbreak News Today
  Wed, 14 Apr 2021 07:00 GMT
• First genetically modified mosquitoes released in the United States - Nature.com
  Mon, 03 May 2021 21:51 GMT
• Valneva Gains in Nasdaq Debut as Rival Vaccine Makers Fall - Barron's
  Thu, 06 May 2021 20:32 GMT
• CARPHA urges greater protection against mosquito-borne diseases during COVID-19 pandemic - Jamaica Gleaner
  Thu, 06 May 2021 19:55 GMT
• Chikungunya may affect central nervous system as well as joints and lungs - EurekAlert
  Wed, 04 Nov 2020 08:00 GMT
• First genetically modified mosquitoes released in US - Livescience.com
  Wed, 05 May 2021 18:31 GMT
• Structural basis of Chikungunya virus inhibition by monoclonal antibodies - pnas.org
  Tue, 03 Nov 2020 08:00 GMT
• Daily briefing: Concussion risk is higher for female soccer players - Nature.com
  Tue, 04 May 2021 18:07 GMT
• Checking on Chikungunya - NASA - NASA - NASA
  Mon, 27 Jul 2020 07:00 GMT
• The First Genetically Modified Mosquitoes Have Just Been Released in The US - ScienceAlert
  Thu, 06 May 2021 01:41 GMT

• PRO> Vector mosquito control - USA: (FL)
  Wed, 05 May 2021 17:31:47 -0400
  Other Human Disease -- United States
  After a decade of fighting for regulatory approval and public acceptance, a biotechnology firm has released genetically engineered mosquitoes into the open air in the United States for the first time. The experiment, launched this week in the Florida Keys (over the objections of some local critics), tests a method for suppressing populations of wild _Aedes aegypti_ mosquitoes, which can carry diseases such as Zika, dengue, chikungunya and yellow fever.
  Oxitec, the firm based in Abingdon,

• Meningoencephalitis associated with Zika virus and Chikungunya virus infection Thu, 06 May 2021 06:00:00 -0400
  Etiology of viral meningoencephalitis is frequently unidentified. Chikungunya virus (CHIKV) and Zika virus (ZIKV) have been known to affect the central nervous system, and should, therefore, be considered for diagnosis of meningoencephalitis since its outcome may be influenced by the etiologic agent, age and immunological condition of the patient. In this study we aimed to determine if CHIKV and ZIKV were the etiological agent of viral encephalitis in meningoencephalitis patients admitted to the...
• Negeviruses reduce replication of alphaviruses during co-infection Thu, 06 May 2021 06:00:00 -0400
  Negeviruses are a group of insect-specific virus (ISV) that have been found in many arthropods. Their presence in important vector species led us to examine their interactions with arboviruses during co-infections. Wild-type negeviruses reduced the replication of several alphaviruses during co-infections in mosquito cells. Negev virus (NEGV) isolates were also used to express GFP and anti-chikungunya virus (CHIKV) antibody fragments during co-infections with CHIKV. NEGV expressing anti-CHIKV...
• Global patterns of aegyptism without arbovirus Wed, 05 May 2021 06:00:00 -0400
  The world's most important mosquito vector of viruses, Aedes aegypti, is found around the world in tropical, subtropical and even some temperate locations. While climate change may limit populations of Ae. aegypti in some regions, increasing temperatures will likely expand its territory thus increasing risk of human exposure to arboviruses in places like Europe, Northern Australia and North America, among many others. Most studies of Ae. aegypti biology and virus transmission focus on locations...
• Use of Cerebrospinal Fluid for the Diagnosis of Neuroinvasive Dengue, Zika, and Chikungunya: A 19-year systematic review Wed, 05 May 2021 06:00:00 -0400
  CONCLUSIONS: Although cerebrospinal fluid analysis is of great importance for increasing neurological diagnostic accuracy and contributes to the early diagnosis of neuroinvasive dengue, chikungunya, and Zika infections, it is underused in routine laboratory investigations worldwide.
• Analysis of a Routinely Used Commercial Anti-Chikungunya IgM ELISA Reveals Cross-Reactivities with Dengue in Brazil: A New Challenge for Differential Diagnosis? Wed, 05 May 2021 06:00:00 -0400
  In Brazil, chikungunya emerged in 2014, and by 2016, co-circulated with other arbovirosis, such as dengue and zika. ELISAs (Enzyme-Linked Immunosorbent Assays) are the most widely used approach for arboviruses diagnosis. However, some limitations include antibody cross reactivities when viruses belong to the same genus, and sensitivity variations in distinct epidemiological scenarios. As chikungunya virus (CHIKV) is an alphavirus, no serological cross reactivity with dengue virus (DENV) should...
• Mucocutaneous manifestations of Chikungunya fever, an experience of tertiary care hospital Tue, 04 May 2021 06:00:00 -0400
  CONCLUSIONS: Chikungunya fever presented with unusual mucocutaneous findings, some of which remained present months or even years after the onset of chikungunya fever.
• "Kankasha" in Kassala: A prospective observational cohort study of the clinical characteristics, epidemiology, genetic origin, and chronic impact of the 2018 epidemic of Chikungunya virus infection in Kassala, Sudan Fri, 30 Apr 2021 06:00:00 -0400
  CONCLUSIONS/SIGNIFICANCE: Vulnerability to CHIKV remains in Kassala and elsewhere in Sudan due to widespread Aedes aegypti presence and mosquito-fostering household water storage methods. This study highlights the importance of increasing awareness of the severity and impact of CHIKV outbreaks, and the need for urgent actions to reduce transmission risk in households.
• The Impact of Health Risk Communication: A Study on the Dengue, Chikungunya, and Zika Epidemics in Curacao, Analyzed by the Social Amplification of Risk Framework (SARF) Fri, 30 Apr 2021 06:00:00 -0400
  Epidemics of dengue, chikungunya, and Zika have been threatening the Caribbean. Since risk communication (RC) plays a fundamental role in preventing and controlling diseases understanding how RC works is essential for enabling risk-reducing behavior. This multimethod qualitative study compares news reports with local's and health professional's perspectives, currently lacking in RC research. It was found that RC strategies were obstructed by a lack of governmental structure, organization, and...
• Favipiravir Does Not Inhibit Chikungunya Virus Replication in Mosquito Cells and Aedes aegypti Mosquitoes Fri, 30 Apr 2021 06:00:00 -0400
  Favipiravir (T-705) is a broad-spectrum antiviral drug that inhibits RNA viruses after intracellular conversion into its active form, T-705 ribofuranosyl 5'-triphosphate. We previously showed that T-705 is able to significantly inhibit the replication of chikungunya virus (CHIKV), an arbovirus transmitted by Aedes mosquitoes, in mammalian cells and in mouse models. In contrast, the effect of T-705 on CHIKV infection and replication in the mosquito vector is unknown. Since the antiviral activity...
• Virome Diversity among Mosquito Populations in a Sub-Urban Region of Marseille, France Fri, 30 Apr 2021 06:00:00 -0400
  Some mosquito species have significant public health importance given their ability to transmit major diseases to humans and animals, making them the deadliest animals in the world. Among these, the Aedes (Ae.) genus is a vector of several viruses such as Dengue, Chikungunya, and Zika viruses that can cause serious pathologies in humans. Since 2004, Ae. albopictus has been encountered in the South of France, and autochthonous cases of Dengue, Chikungunya, and Zika diseases have recently been...